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An innovative microscope developed by a research team at the Hong Kong University of Science and Technology (HKUST) is poised to revolutionise the field of cancer surgery. This cutting-edge microscope, powered by artificial intelligence, has the potential to transform the way surgeons detect and remove cancerous tissue during operations, thereby sparing patients from the distressing prospect of secondary surgeries.
Lung cancer, a leading cause of cancer-related deaths worldwide, has been a focal point for this ground-breaking research. Professor Terence Wong Tsz-Wai, the principal investigator of the project and an assistant professor in the Department of Chemical and Biological Engineering at HKUST, highlights the urgency of their work.
He notes that between 10% to 20% of lung cancer surgery cases require patients to return for a second operation due to incomplete removal of cancer cells. This uncertainty has long plagued surgeons, who often struggle to determine if they’ve successfully excised all cancerous tissue during the initial surgery.
The HKUST research team, led by Prof. Wong, is eager to see their innovation make a significant impact. Collaborating with five hospitals, including Queen Mary Hospital, Prince of Wales Hospital in Hong Kong, and three mainland Chinese hospitals, they have embarked on a large-scale clinical trial involving around 1,000 patient tissue samples. The goal is to have the microscope officially in service locally by 2024 and on the mainland by 2025.
The current methods for imaging cancer tissue offer either accuracy with lengthy delays or speed at the cost of accuracy. Traditional microscopy, considered the gold standard, is highly accurate but can take up to a week to generate results. This means patients must endure a week of anxious waiting to know the outcome of their surgery. In cases where the operation is deemed unsuccessful, patients face the daunting prospect of a second surgery to remove the remaining cancer cells.
The alternative, known as the frozen section, provides quicker results within 30 minutes but sacrifices accuracy, with an estimated accuracy rate of only around 70%.
The HKUST research team’s breakthrough technology, termed “Computational High-throughput Autofluorescence Microscopy by Pattern Illumination” (CHAMP), has changed this landscape. It can detect cancer cells in just three minutes with an accuracy rate exceeding 90%, rivalling the gold standard but with significantly faster results.
CHAMP employs ultraviolet (UV) light excitation to image tissue surfaces at a specific wavelength. Subsequently, a deep learning algorithm transforms the obtained greyscale image into a histological image, facilitating instant interpretation by doctors. This real-time feedback empowers surgeons to ensure they have completely removed all cancer cells during the operation.
CHAMP’s potential has garnered local, regional, and international acclaim, leading to the establishment of a start-up supported by HKUST and funded by the Technology Start-up Support Scheme for Universities (TSSSU). Beyond developing the technology, the company plans to manufacture CHAMP microscopes for medical institutions in Hong Kong, mainland China, and overseas markets.
This endeavour represents the culmination of years of meticulous research, starting with Prof. Wong’s PhD training at Washington University in St. Louis and the California Institute of Technology. During this period, Prof. Wong, under the guidance of biomedical imaging expert Prof. Lihong Wang, developed a microscope capable of analysing breast cancer tumours with an accuracy rate comparable to the gold standard but with results in just one to two hours.
The shift in focus to lung cancer occurred when a pulmonologist approached Prof. Wong, recognising the potential of the technology to enhance precision during lung cancer surgery. This decision led to the development of CHAMP microscopy, which is approximately 100 times faster than Prof. Wong’s earlier work during his PhD training. This breakthrough makes CHAMP clinically useful and impactful.
The applications of CHAMP extend beyond lung and breast cancers. The research team is conducting tests on smaller scales for conditions such as liver, colorectal, kidney, and skin cancers, as well as prostate gland conditions. Prof. Wong is confident that CHAMP will elevate medical imaging and diagnosis to new heights, benefiting not only Hong Kong hospitals but also healthcare institutions nationwide and abroad. This pioneering technology represents a beacon of hope for cancer patients, offering the promise of quicker, more accurate surgeries and improved outcomes.
OpenGov Asia reported that the Hong Kong Science and Technology Parks Corporation (HKSTP) spearheaded an initiative aimed at promoting innovation and technology in the biotech sector, showcasing Hong Kong’s pioneering advancements and entrepreneurial spirit.
This initiative was part of the “Think Business, Think Hong Kong” event organised by the Hong Kong Trade Development Council (HKTDC) in Paris recently. The event was a platform to underscore the potential for cross-border collaboration between Hong Kong and France in the field of biotechnology and innovation.
