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Singapore Advancing Cardiovascular Science with AI

The National Heart Centre Singapore (NHCS) has been on a remarkable journey of advancements in cardiovascular research, particularly in the prevention, diagnosis, and management of heart diseases. With the global rise in heart disease cases, NHCS’s dedication to scientific knowledge and innovation has become increasingly vital.

Since its establishment in 2014, the National Heart Research Institute of Singapore (NHRIS) at NHCS has positioned itself as a leading institution for cardiovascular research in the region. Over the years, NHRIS has achieved significant breakthroughs that hold the potential to transform patient outcomes.

NHRIS’s research encompasses a wide spectrum of disciplines within cardiovascular medicine, spanning basic, translational, and clinical research. Notable achievements include Heart Stem Cell Therapy and Preventing Fibrosis.

By studying patients’ heart stem cells, researchers have uncovered new treatments for heart diseases. For example, a breakthrough treatment using myeloperoxidase has been discovered for hypertrophic cardiomyopathy, an inherited condition characterised by thickening of the heart muscle.

Also, through the study of heart tissue from patients undergoing surgery, NHRIS researchers have identified a potential treatment involving interleukin-11 antibodies to prevent inflammation and fibrosis in the heart and other organs. This innovative therapy has the potential to improve outcomes for patients with various inflammatory and fibrotic conditions.

The next phase of NHCS’s research efforts over the coming years will focus on three key areas:

  • Discovery of New Treatments: Ongoing research aims to develop new treatments for heart diseases, enhancing patient outcomes.
  • Utilising Artificial Intelligence: NHCS is at the forefront of integrating artificial intelligence (AI) into cardiovascular care. AI holds promise in predicting, diagnosing, and monitoring heart diseases with greater precision and efficiency. The APOLLO study, initiated in 2021, is building an AI-driven national platform for coronary angiography analysis, offering detailed reports on patients’ conditions and future cardiovascular disease risk.
  • Clinical Trials and Population Health Studies: NHCS’s research agenda includes conducting clinical trials and population health studies to prevent the onset of heart disease.

NHRIS is pioneering innovative approaches, including Visualising Energy Pathways and AI Applications.

Disturbances in energy-producing pathways in heart muscle contribute to heart conditions as Hyperpolarised magnetic resonance spectroscopy, a novel imaging technology available only in a few centres worldwide, allows the measurement of these metabolic pathways, potentially leading to new treatments for heart disease.

On the other hand, AI accelerates research in the field of cardiovascular science. By processing vast datasets and identifying patterns, AI systems assist researchers in identifying novel treatment methods, risk factors, and disease mechanisms. These insights lead to breakthroughs in treatment and prevention methods, advancing the overall understanding of cardiovascular diseases.

With this, NHCS is leveraging AI to detect, predict, and diagnose heart diseases by analysing complex imaging data. AI provides clinicians with invaluable insights, enabling personalised care and early intervention.

In addition, NHCS collaborates with other heart research institutes and hospitals through CADENCE (Cardiovascular Disease National Collaborative Enterprise), a national platform that combines heart research capabilities in data science, clinical trials, and AI. This collaboration ensures a collective effort to advance cardiovascular research and improve patient care.

NHCS’s groundbreaking research initiatives in AI applications, clinical trials, and collaborative efforts underscore its commitment to enhancing patient care. As NHCS continues its pursuit of research excellence, its impact extends beyond Singapore, benefiting individuals across the region and around the world. The institution is poised to make substantial progress in preventing, diagnosing, and managing cardiovascular diseases, ultimately reshaping the future of cardiovascular medicine.


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