February 22, 2024

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Singapore UTD’s M2E Device Offers Cheap Cancer Treatment

Medical Records Technology with a vitruvian man over a background of digital binary code as a health care symbol of electronic data storage at a central server network available in the cloud for a hospital or clinic patient convenience.

Researchers from the Singapore University of Technology and Design (SUTD) have invented a microsize-gap multiple-shot electroporation (M2E) device that has the potential to increase the efficiency with which cancer treatment is offered at a cheaper cost. The researchers came to the conclusion that the instrument would benefit from having transparent electrodes installed in it so that it could better visualise anti-cancer medications.

According to Desmond Loke, an assistant professor at SUTD and the primary investigator of this research, the scientific community wants to create a simple, low-cost cancer treatment system. “The narrow gap between electrodes allows us to achieve a sufficiently strong electric field using a few volts rather than several tens of volts applied in traditional electroporation.”

Assistant Prof. Loke revealed that the device that was built by SUTD did not require any specialised components, expensive materials, or a tedious fabrication process. He stated that this was one of the most important aspects of the device.

The M2E device, which is connected to the development of cancer treatments, was put through its paces by researchers utilising a variety of substances. Because of this new technology, cancer cells can now display a two-hour window in which they are able to take in chemicals.

The time frame offered by conventional electroporation equipment is approximately 400% shorter than what is supplied. In addition to that, it may be utilised more than once. According to the results of the study, the M2E system has the potential to be beneficial in the treatment of COVID-19 when combined with associated drugs.

Electroporation is a technique that involves the application of a very weak electric pulse to cells in order to momentarily create holes in the membranes of such cells. The goal of this technique is to transfer genetic material across cells. The goal of using this method is to facilitate the movement of chemicals into and out of the cells.

This method has the potential to increase the likelihood of drug delivery for the treatment of cancer patients. The chemotherapy and radiation therapies for cancer can be administered through these holes if they are large enough. It is possible that the effectiveness of cancer treatments, as well as patients’ access to those treatments, could be improved through the integration of electroporation into treatment protocols.

This contrasts with how electroporation was traditionally performed, in which several tens of volts were applied. This low voltage, together with the transparent electrode, serves to minimise energy use and facilitate visibility, avoiding dangerous drug use and restricted imaging of drug transport during drug testing, both frequent concerns with conventional electroporation devices. Low voltage also prevents dangerous drug use.

In addition, the permeability of tumour cells can be improved through the utilisation of electroporation in the treatment paradigm of electrochemotherapy to achieve the desired outcomes. Because of this, the cancer cells can more effectively absorb chemotherapy drugs like bleomycin and cisplatin.

After the researchers have finished working on ways to improve the M2E system, they anticipate that it will be a few years before the device finishes the clinical study and is ready for widespread use. The M2E technology has the potential to pave the way for much-enhanced delivery of cancer medicines and a more uniform distribution of cancer treatments to under-resourced and underserved places all over the world.

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Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

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CTC Global Singapore, a premier end-to-end IT solutions provider, is a fully owned subsidiary of ITOCHU Techno-Solutions Corporation (CTC) and ITOCHU Corporation.

Since 1972, CTC has established itself as one of the country’s top IT solutions providers. With 50 years of experience, headed by an experienced management team and staffed by over 200 qualified IT professionals, we support organizations with integrated IT solutions expertise in Autonomous IT, Cyber Security, Digital Transformation, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

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Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

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SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

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HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

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IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.

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