Close this search box.

We are creating some awesome events for you. Kindly bear with us.

HKUST paves way for antibiotics against superbugs with antibiotics resistance mechanism discovery

HKUST paves way for antibiotics against superbugs with antibiotics resistance mechanism discovery

to a recent
press release
, researchers at the Hong Kong University of Science and
Technology (HKUST) have identified the mechanism behind broad-spectrum
bacterial resistance to peptide antibiotics.

team of researchers are led by Professor Qian Pei-Yuan, Chair Professor from
the Division of Life
. Prof Qian is also David von Hansemann Professor of Science and
Acting Head of the Department of Ocean Science at HKUST.

discovery opens a new direction to the design of new drugs in tackling
superbugs, as peptide antibiotics is widely perceived as the last-line of
defense against antibiotic-resistant bacteria.

antibiotics – including vancomycin and polymyxin for respective treatment
of Staphylococcus Aureus (CA-MRSA)
Infection and Escherichia coil infection,
are often used as the last resort due to their resilience to multidrug
resistant bacteria. 

a few years ago, scientists have started identifying a few types of peptide
antibiotics which have developed symptoms of bacterial resistance, although the
causes behind such phenomenon remained unknown. 

following the analysis of over 6,000 bacteria genomes under repeated validation
through gene editing, chemical and enzymatic analyses, Prof Qian’s team
eventually identified a family of D-stereospecific resistance peptidases (DRPs)
as the source of the problem, and its magnitude extends well beyond a few
strains of bacteria.

team also discovered that the DRPs enzyme, which they identified as the cause
of broad-spectrum bacteria resistance against peptide antibiotics, is found in
not just a few, but many different strains of bacteria, sounding an alarm
against persistent improper use of antibiotics.

are phylogenetically widely distributed in nature, if they are transferred to
opportunistic pathogens with human’s increasing misuse and
overuse of antibiotics, more and more peptide antibiotics would be
rendered useless, leading to delay or even failure in treatment,” said Prof

to Prof Qian, misuse and overuse of antibiotics of humans will intensify the problem
of antibiotic resistance of pathogens, that makes research on peptide
antibiotics even more important.

our understanding of antibiotic resistance mechanisms to peptide antibiotics
does not only serve as a wake-up call but is also conducive to increasing our
collective antibiotic arsenal. The findings of DRPs is just the beginning, we
hope it will lead to more research on the use and development of peptide
antibiotics,” he added

The findings of Prof Qian and his fellow
researchers were recently published in the scientific journal Nature Chemical Biology.


Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.


As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Renowned for our consulting expertise and delivering expert IT solutions, CTC Global Singapore has become the preferred IT outsourcing partner for businesses across Singapore.


Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit


SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.


HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 


IBM is a leading global hybrid cloud and AI, and consulting services provider, helping clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,800 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently, and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity, and service. For more information, visit