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Taiwan’s EEG-Aided System for Screening of Dementia in Alzheimer’s

Supported by Taiwan’s Ministry of Science and Technology (MOST), the interdisciplinary research team at the National Taiwan University of Science and Technology (NTUST), has successfully developed the world-first electroencephalography (EEG)-based computer-aided diagnosis (CADx) system for rapid screening of both dementia due to Alzheimer’s disease (AD) and its prodromal phase – the mild cognitive impairment (MCI).

The development was made possible by integrating different domains’ technologies, including EEG signal processing, circuits and electronics, Artificial Intelligence, cognitive neuroscience and medical science. The EEG-based CADx system has demonstrated high accuracy and high usability and, therefore, has great potential to provide an objective measure to assist MCI diagnosis, facilitating early intervention and reducing the risk of developing into Alzheimer’s dementia.

According to the Alzheimer’s Disease International (ADI), There are currently estimated to be over 55 million people worldwide living with dementia.  A new case of dementia arises somewhere in the world every 3 seconds. The number of people affected is projected to rise up to 139 million by 2050. In Taiwan, 291,961 elders suffer from this disease, occupying 7.7% of the older population. Currently, there is still no effective treatment for neurodegenerative diseases such as AD.

Mild cognitive impairment (MCI) is a state between cognitive declines with normal ageing and cognitive impairments caused by dementia due to AD. The MCI is a common condition in the older population, and individuals with MCI are at higher risk to develop AD in their later stages.

However, MCI is usually underdiagnosed in the community because older adults with MCI are often not aware of subtle declination of their cognitive function, which primarily prevents them from seeking medical advice or even interventions. Therefore, a safe, objective and easy-to-implement method for accurate and efficient classification of individuals with MCI and healthy individuals is essential to promote early intervention of MCI.

The researchers have delved into the research of EEG-based diagnosis for AD and MCI. The research team has developed the nonlinearly multiple EEG feature decoding technique, and identified the most MCI-sensitive brain areas by using machine learning methods. An automatic EEG classification algorithm superior to the state-of-the-art methods was also proposed and embedded in the AI model, achieving a leading MCI detection accuracy of 90%. The related research outcomes have been published in different journals.

The EEG-based CADx system consists of three components, sensors (surface electrodes), EEG amplifier (analogue signal acquisition and processing), and software (AI model). It has the advantages of convenience safety (non-invasive), efficiency, and high accuracy (90%). Compared with other neuroimaging approaches, functional MRI for example, this technology is, therefore, more suitable for a routine screen of MCI and AD.

Taiwanese researchers have been developing advanced technologies to diagnose diseases, including leukaemia. As reported by OpenGov Asia, a research team led by National Taiwan University Hospital (NTUH) developed Artificial Intelligence (AI) system that speeds up leukaemia diagnosis after completing trials at four medical institutions in Taiwan and the United States.

The trials have conducted assessments and differential counting of bone marrow smears which are used for leukaemia diagnosis. A total of 254 patients were involved in the trials. The diagnosis results using the AI system reached a matching rate of 70-90% with those by a human doctor. The AI system has received approval from Taiwan’s Ministry of Health and Welfare and the European Union for marketing as an AI medical device.

NTUH believes that the future of our medicine will be built mainly around holistic and personalised healthcare. On the basis of humanistic care of better quality, NTUH will be able to appropriately utilise electronic information and biotechnology to form the foundation of our management and raise their service quality to international standards. NTUH has been adapting in the past to the changing times and shifts in the environment by carrying out a series of organisational reconstruction and R&D programs.

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Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

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As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

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SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

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HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

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IBM is a leading global hybrid cloud and AI, and consulting services provider, helping clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,800 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently, and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity, and service. For more information, visit www.ibm.com