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New Technology Detects and Reverses Opioid Overdose

Image credits: newsroom.uw.edu

A research team at the University of Washington (UW) has developed a wearable device to detect and reverse an opioid overdose. The device, worn on the stomach like an insulin pump, senses when a person stops breathing and moving, and injects naloxone, a lifesaving antidote that can restore respiration.

The opioid epidemic has become worse during the pandemic and has continued to be a major public health crisis. We have created algorithms that run on a wearable injector to detect when the wearer stops breathing and automatically inject naloxone.

– Justin Chan, Lead Author and PhD student, UW’s Allen School of Computer Science & Engineering

Co-author Jacob Sunshine, an associate professor of anesthesiology and pain medicine at the UW School of Medicine, said one of the unique aspects of opioid overdoses is that naloxone, a benign drug, is highly effective and can save lives if it can be administered in a timely fashion.

The UW team is looking to make these devices widely available, which would first require approval by the U.S. Food and Drug Administration.  The FDA is currently working to accelerate efforts to address this critical public health problem and has recently released special guidance on emergency-use injectors.

In a multiyear collaboration, the UW investigators worked on the prototype with West Pharmaceutical Services of Exton, Penn, which developed a wearable subcutaneous injector that safely administers medications. The research team combined this injector system with sensors and developed an algorithm to detect the life-threatening pattern of respirations that occur when people experience opioid toxicity.

Co-author Shyam Gollakota, a UW professor of computer science and engineering, said the device could help people at different stages of opioid-use disorder to avoid accidental death. This wearable auto-injector may have the potential to reduce fatalities due to opioid overdoses.

The pilot device includes a pair of accelerometers that measure respiration and an onboard processor that detects the halt of motion associated with breathing. The wearable system, which has received regulatory approval in the United States, activates the injector in the presence of prolonged apneic events. The device also can transmit data about breathing rates and apneic motion to a nearby smartphone via Bluetooth.

To test the device, a clinical study was conducted with volunteers in a supervised injection facility in Vancouver, B.C., and a parallel clinical trial was conducted in a hospital environment among volunteers who manifested signs of apnea by holding their breath. The injection facility deployment was crucial, the researchers said, to help develop breathing algorithms involving real-world, opioid-induced breathing changes.

Twenty-five participants were recruited. The sensors were able to accurately track respiration rates among people with opioid-use disorder. Further, the device was able to detect non-medical, opioid-induced apnea, a breathing pattern that commonly precedes a potentially fatal overdose. The testing in Vancouver measured breathing patterns only to develop the respiratory algorithm and did not involve an injection of naloxone, which was administered only in the second study involving healthy human volunteers who did not take opioids.

In the second study, 20 participants simulated overdose events in a hospital setting by breathing normally, then performing a breath-hold for 15 seconds to mimic an apneic event. When the wearable system detected that the subject had not moved for at least 15 seconds, it activated and injected naloxone into the participant.

Researchers said further studies are needed to assess the comfort and discreteness of the device over longer time periods, particularly in unsupervised settings. And, they said, additional study of the device is needed to evaluate naloxone injection in people who use opioids for nonmedical purposes.

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