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Singapore: Innovative Imaging Revolutionises Cancer Diagnosis 

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Medical imaging can give doctors a clear picture of what’s happening inside the body. This can help them recognise diseases early and start treatment immediately, which is better for the patient. Also, medical imaging can help doctors understand how diseases get worse and develop new ways to treat them.

With this, researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS), led by Assistant Professor Anand Jeyasekharan, have found a unique combination of oncogenes that could predict treatment resistance and, therefore, bad outcomes for patients with Diffuse large B cell lymphoma (DLBCL), the most common type of blood cancer in Singapore and around the world.

The most up-to-date technology can find this unique oncogenic mix, which shows that the cancer is resistant to treatment. However, the researchers went a step further and made a simple mathematical formula that could predict the percentage of cells based on information from well-known diagnostic methods. This makes it possible for this oncogene indicator to be used regularly in clinical practice.

Oncogenes are very important in the development of cancer because they control the production of “bad” oncoproteins that help cancer grow and stay alive and affect how well the treatment works. But cancers often have more than one of these oncogenes, and not every cancer cell has every oncogene.

Since oncogenes are usually studied one at a time, not much is known about how the “co-existence” of oncogenes in certain types of cancer cells affects a cancer patient’s chance of life. To address this knowledge deficit, the research team investigated whether and how oncogenes collaborate to resist treatment in DLBCL.

Immunohistochemistry, which measures MYC, BCL2, and BCL6, three oncogenes, is frequently used in clinical practice to detect high-risk DLBCL cases. Immunohistochemistry, on the other hand, is unable to concurrently detect these three oncogenes, making it impossible to spot cell subgroups that have oncogenic combinations.

Hence, the researchers used cutting-edge imaging technology known as multispectral microscopy with quantitative immunofluorescence to overcome this obstacle. This technique enables researchers to stain, photograph, and quantify several proteins in a single sample.

This is accomplished by the excitation of various proteins with various light wavelengths, enabling distinct visualisation of each protein. Since the method is quantitative, it is possible to gauge how much of each protein is present.

Multispectral microscopy with quantitative immunofluorescence would not be achievable without digital technology. This technique requires the ability to record, store, process, and analyse images at such high quality. With the help of digital technology, it is now feasible to analyse proteins in a much more in-depth and quantitative manner, which has improved knowledge of the molecular alterations linked to cancer.

Compared to older imaging technologies, this one has several benefits. First, it enables researchers to examine a variety of proteins at once, which can help them develop a more thorough understanding of the molecular alterations linked to cancer. Second, because the method is quantitative, scientists can quantify each protein and utilise that information to find biomarkers that can be used to detect and monitor the development of cancer.

In addition, this technology can completely alter how cancer is discovered and treated. This technology could result in the creation of fresh and more potent cancer treatments by giving researchers a more thorough grasp of the molecular alterations linked to cancer.

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Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

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As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Renowned for our consulting expertise and delivering expert IT solutions, CTC Global Singapore has become the preferred IT outsourcing partner for businesses across Singapore.

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Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

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SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

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HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

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IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.