Close this search box.

We are creating some awesome events for you. Kindly bear with us.

Advancing Diagnostics with More Powerful Biosensors

Researchers at the National Institute of Standards and Technology (NIST) in the United States (U.S.) have developed biosensors to detect the presence of or predisposition to various illnesses, including cancer. A novel biosensor chip with an accurate and low-cost architecture may enhance access to high-quality examinations.

The capacity to detect these signs, called biomarkers, enables medical practitioners to make vital early diagnoses and give individualised therapies. Because traditional screening procedures might be time-consuming, costly, or limited in what they can reveal, they also combined the biosensors with extremely low-power FET Internet of Things (IoT) devices to boost the sensors’ responsiveness. The FET was created at CEA-LETI to amplify signals in smartwatches, personal assistants, and other gadgets.

“This is a scalable technique. In principle, we can integrate hundreds, if not thousands, of sensors in an area of one square millimetre into a console the size of a smartphone, which is far less burdensome than some of the latest equipment used in the clinic,” said NIST researcher Arvind Balijepalli, a co-author of the new study developed by researchers at NIST Brown University and the French government-funded research institute CEA-Leti.

The researchers reported the results of a study that proves the device’s excellent sensitivity and precision despite its modularity, which is commonly associated with decreased performance, in a paper recently uploaded online from the 2018 IEEE International Electron Devices Meeting.

DNA sensor

The biosensor recognises biomarkers by detecting how DNA threads bond to the device. Its modular architecture distinguishes it from related sensors, lowering costs by making mass production more accessible and allowing the most expensive parts to be reused.

Like other DNA biosensors, the device makes use of the fact that a single DNA strand is ready for chemical bonding when it is not coupled with another within the recognisable double helix. Instead, a portion of the device has single strands of DNA coated on it. When these “probes” come into contact with DNA biomarkers with a matched or complementary genetic sequence, the two strands join, sending a signal that the gadget detects.

When a strand of target DNA binds to a probe, it causes a voltage shift that may be measured using a semiconductor device called a field-effect transistor (FET). As the molecules pop on and off the sensor, these voltage shifts can occur hundreds of times per second. This method tells you whether a DNA strand is attached to a probe and how long it takes to connect and disengage.

Improving signal detection

FET-based methods have yet to hit the mainstream, however. A significant stumbling block is their single-use nature, which has now seemed necessary but has increased its cost. The signal gets harder to measure because of the electrical signal’s noise when they must travel longer within electronics.

DNA probes in FET-based sensors usually are attached to the transistor directly, which converts the signal into readable data and limits noise. But the probes and whole device signal are weaker after exposure to a sample. Then they utilise the Internet of Things (IoT) FET to accommodate the losses. The NIST authors paired their circuitry with a specific type of low-power FET developed at CEA-LETI that is used in smartwatches, personal assistants, and other devices to amplify signals and compensate for the lost sensitivity.

The researchers found that the binding kinetics were sensitive enough to make accurate measurements even at low concentrations. Overall, the modular design performed similarly to integrated, nonmodular FET-based biosensors. The modular design performed similarly to integrated, nonmodular FET-based biosensors. The next step in their research is determining if their sensor can perform similarly with varying DNA sequences caused by mutations. Because many diseases are caused or exacerbated by altered DNA, this skill is critical for clinical diagnosis.


Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.


As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Renowned for our consulting expertise and delivering expert IT solutions, CTC Global Singapore has become the preferred IT outsourcing partner for businesses across Singapore.


Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit


SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.


HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 


IBM is a leading global hybrid cloud and AI, and consulting services provider, helping clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,800 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently, and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity, and service. For more information, visit