Search
Close this search box.

We are creating some awesome events for you. Kindly bear with us.

AI for Personalised Myeloid Leukaemia Treatment in Singapore

Researchers from Singapore General Hospital (SGH), A*STAR’s Genome Institute of Singapore (GIS), and Duke-NUS Medical School have used artificial intelligence (AI) to speed up the identification of vital biomarkers that can identify patients with chronic myeloid leukaemia (CML) at diagnosis who will not respond to standard therapy.

These patients may be eligible for a life-saving bone marrow transplant in the early stages of the illness with this favourable prognosis.

A genetic mutation that causes a tyrosine kinase enzyme to turn on permanently causes CML, a specific type of blood cancer.  In the bone marrow, a blood stem cell experiences a mutation that transforms it into an aggressive leukaemic cell that eventually takes over the creation of healthy blood.

Tyrosine kinase inhibitors (TKI), which turn off the tyrosine kinase that the genetic mutation switched on as a result, are the standard treatment for CML. But not everyone reacts the same way to these medications. Some individuals respond very well to the point that their life expectancy would be regarded as typical, at the other end of the range.

Besides, some individuals do not respond at all, and their sickness develops into a severe condition known as a blast crisis that is resistant to all sorts of conventional therapy.

Finding out if a patient is resistant to TKI therapy earlier could make the difference between survival or early death because the only cure for blast crisis is a bone marrow transplant, which would be most successful when carried out during the early stages of the disease.

“Our work indicates that it will be possible to detect patients destined to undergo blast crisis when they first see their haematologist,” said the study’s senior author and associate professor, Ong Sin Tiong of Duke-NUS’ Cancer & Stem Cell Biology (CSCB) Programme.

He added this may save lives since bone marrow transplants for these patients are most effective during the early stages of CML.

Researchers made an “atlas” of cells by taking samples of bone marrow from six healthy people and 23 people with CML before they were treated. The map let them see the different types of cells in each sample and how many of each type there were. Researchers did RNA sequencing on a single cell and used machine-learning methods to figure out which genes and molecular processes were on and off in each cell.

The work found eight statistically important things about the bone marrow cells before treatment. These things were linked to either sensitivity to treatment with a tyrosine kinase inhibitor or strong resistance to it.

Patients were more likely to react well to treatment if their bone marrow samples showed a stronger tendency toward premature red blood cells and a certain type of “natural killer cell” that kills tumours. As the number of these cells in the bone marrow changed, so did the way the patient responded to treatment.

The study could lead to drug targets that could help people with chronic myeloid leukaemia avoid or delay treatment resistance and blast crisis.

Associate Professor Charles Chuah from Duke-NUS’s CSCB Programme, who is also a Senior Consultant at the Department of Haematology at SGH and National Cancer Centre Singapore (NCCS), cited that the results of treating chronic myeloid leukaemia have gotten much better over the years and that patients now have many options. Knowing which treatment works best for each patient will improve these results even more, and they are excited about the chance of doing so.

The team hopes to use the results to make a test that can be used regularly in hospitals to predict how well a treatment will work.

PARTNER

Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

PARTNER

As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Renowned for our consulting expertise and delivering expert IT solutions, CTC Global Singapore has become the preferred IT outsourcing partner for businesses across Singapore.

PARTNER

Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

SUPPORTING ORGANISATION

SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

PARTNER

HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

PARTNER

IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.