Close this search box.

We are creating some awesome events for you. Kindly bear with us.

Indonesia: New Frontiers in Global Health Security

Getting your Trinity Audio player ready...

The breakthrough at the Eijkman Molecular Biology Research Centre of the National Research and Innovation Agency (BRIN), led by researcher Yudhi Nugraha and his team in Madrid, Spain, has advanced molecular biology to a pivotal point with the creation of Spikebodies. This innovative technology, developed between 2021 and 2023, stands poised to make significant contributions to global health, particularly in combating the SARS-CoV-2 virus.

Image credits:

During the session, Yudhi explained the development and potential of Spikebodies. “We have successfully designed and developed two nanobodies and determined their structures using Cryo-EM,” Yudhi announced. He highlighted a critical step in understanding and manipulating virus behaviour at a molecular level.

The significance of spike proteins was central to Yudhi’s presentation. These proteins are crucial in the context of the pandemic because they facilitate the virus’s entry into human cells by binding to the ACE2 receptor. “Spikebodies are designed to block this interaction between the ACE2 receptor and the SARS-CoV-2 spike, effectively preventing the virus from entering human cells,” Yudhi explained. This blocking is achieved through biotechnological processes, including protein expression, purification, and detailed structural determination using both Cryo-EM and X-ray Crystallography.

Looking ahead, Yudhi shared his strategic vision for the application of nanobody technology: “Our next strategic target is to utilise this technology to prevent all types of viruses through adaptation to structural differences in key proteins responsible for transmission.”

In stressing the role of structural biology, Yudhi discussed how this field is pivotal for unlocking the mysteries of molecular biodiversity. The Cryo-EM technology at BRIN, for instance, allows researchers to visualise structures at an atomic level, providing a deep understanding of biological mechanisms and pathways.Cryo-EM is a method that determines the 3D structures of biomacromolecules, such as proteins and nucleic acids, by imaging them at cryogenic temperatures.

Yudhi said this research not only sheds light on fundamental biological processes but also paves the way for the development of targeted medical interventions such as drugs, antibodies, and nanobodies. “Cryo-EM technology allows us to see and understand the machinery of viruses at a molecular resolution, which is crucial for developing effective strategies against viruses like SARS-CoV-2,” he stated.

Yudhi also elaborated on how the structural biology approach aids in understanding the transmission mechanisms of viruses, thereby enabling researchers to design antibodies that are finely tuned to combat viruses effectively. “By deciphering the virus’s structure, we gain insights into its interaction patterns and lifecycle within the host cell, which is instrumental in crafting potent antibodies,” he explained.

Moreover, this approach’s adaptability is key, especially as viruses evolve. “Even when the virus mutates to evade the existing immune defences, we can quickly adapt by designing new nanobodies that are effective against the mutated variants,” Yudhi noted.

This deep dive into the structural understanding of molecules is foundational in the field of structural biology, which stands at the forefront of designing proteins that can meet specific health needs and address particular biological challenges.

Yudhi believed that the development of Spikebodies represents a significant leap forward in the ongoing battle against pandemics. Harnessing cutting-edge technologies like Cryo-EM is not only advancing the fundamental understanding of virus behaviour but also developing innovative tools to mitigate these threats effectively. “This integration of digital technology and molecular biology illustrates the powerful synergy that can lead to transformative solutions in global health security,” Yudhi asserted.


Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.


CTC Global Singapore, a premier end-to-end IT solutions provider, is a fully owned subsidiary of ITOCHU Techno-Solutions Corporation (CTC) and ITOCHU Corporation.

Since 1972, CTC has established itself as one of the country’s top IT solutions providers. With 50 years of experience, headed by an experienced management team and staffed by over 200 qualified IT professionals, we support organizations with integrated IT solutions expertise in Autonomous IT, Cyber Security, Digital Transformation, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Well-known for our strengths in system integration and consultation, CTC Global proves to be the preferred IT outsourcing destination for organizations all over Singapore today.


Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit


SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.


HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 


IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.