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CUHK Develops Microrobot

Image Credits: CUHK, Press Release

The Chinese University of Hong Kong (CUHK)’s cross-disciplinary research team developed a magnetic helical microrobot with endoscope-assisted delivery for biofilm eradication in ear tubes. The novel treatment procedure has been validated in a human cadaver ex vivo, which is a promising sign for clinical application. Study results have been published in the international journal Science Advances.

About 7% of children under the age of six have had otitis media with effusion. The fluid may resolve on its own within a few weeks but if the condition prevails, surgical treatment becomes necessary. Insertion of an ear tube into the tympanic membrane is a procedure to treat otitis media with effusion. In Hong Kong, it is common for adult or child patients to undergo an implant of an ear tube for otitis media with effusion.

Biofilm builds up in the ear tube over time and contributes to otorrhea, or drainage of fluid from the ear, and debris deposition, which in turn can cause blockages and recurring infections. For severely blocked ear tubes, surgeons must use specialised mechanical tools to clear the occlusion or replace the ear tube during endoscopy. This manoeuvre requires delicate expert skills to avoid injuries to the ossicular chain and tympanic membrane.

The Assistant Professor in the Department of Otorhinolaryngology, Head and Neck Surgery at CU Medicine explained that recurrent infections of ear refractory to antibiotic treatment and occlusion of the ear tube are complications related to biofilms after an operation.

Usually, antibiotics are used to prevent biofilm occlusion after surgery. However, they cannot prevent infection in the long term, and may lead to antimicrobial resistance. Some patients who suffer from ear tube occlusion require frequent tube replacement, which increases their physical and financial burden.

Hence, a research team with members from the Department of Mechanical and Automation Engineering at Faculty of Engineering, and the Department of Otorhinolaryngology, Head and Neck Surgery at CU Medicine joined hands to develop a magnetic helical microrobot with endoscope-assisted delivery for biofilm eradication in ear tube.

The treatment system consists of helical microrobot, endoscope, magnetic actuation unit with robotic arm, and catheter. Surgeons first use an endoscope to deliver the helical microrobot with a catheter into the ear tube. Then they can remotely actuate the microrobot by the programmed magnetic field in the ear tube to perform biofilm eradication.

A Professor from the Department of Mechanical and Automation Engineering said that microrobots have both chemical and mechanical methods of eradicating biofilm. The precision movement of the microrobot enables it to perform tasks harmlessly in a confined space with high accuracy while inducing no pain.

Meanwhile, the Associate Professor in the Department of Otorhinolaryngology, Head and Neck Surgery at CU Medicine stated that the novel treatment procedure has been validated in a human cadaver ex vivo, which is a promising sign for clinical application.

The invention can provide a more manageable alternative to the current treatment and alleviate the physical and psychological pressure from repetitive ear tube replacement. Looking ahead, the team will acquire more evidence about the safety and stability of the system to promote clinical application.

The Dean of Lee Kong Chian School of Medicine and CUHK’s Emeritus Professor noted that while biofilm has been known for quite some time, the clearance of biofilm has been an unsolved problem for decades. So far, no medication has proven to be useful in clearing the microbes once they are established on the surface as a layer. This study represents a breakthrough using both mechanical and chemical methods in the same modalities. Its application is not limited to ear tubes for otitis media: potentially it can be used in other medical devices or implants placed in the human body where biofilm infections can occur.

This study was supported by Research Grants Council, Innovation and Technology Commission, Chow Yuk Ho Technology Centre for Innovative Medicine, CUHK T Stone Robotics Institute, Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences (CAS) – CUHK Joint Laboratory of Robotics and Intelligent Systems, and Multi-scale Medical Robotics Center under InnoHK.

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