February 29, 2024

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Griffith Uni Researchers Develop Cancer Detection Tech

Image Credits: Griffith Uni, Press Release

Griffith University researchers have developed a new way to detect cancer biomarkers that could help diagnose early-stage disease.

Led by Associate Professor Muhammad Shiddiky from the Queensland Micro and Nanotechnology Centre and Professor Bernd Rehm, Director of the Centre for Cell Factories and Biopolymers at the Griffith Institute for Drug Discovery, the research team designed an inexpensive and sensitive way of detecting ovarian cancer and other diseases using a new class of superparamagnetic nanomaterials.

They bioengineered cell factories to assemble nanobeads with magnetic properties that bind to specific target antibodies. Then the magnetised nanobeads were added to ovarian cancer cells to capture methylated DNA and exosomes (cells) to detect cancer.

The nanomaterials can be engineered according to the need for detecting a certain disease type, they are highly flexible and can be tuned for almost any kind of biological molecules that are relevant to detect specific diseases. Once the disease molecules have been ‘captured’ by the nanomaterial, they can be easily isolated and separated from bodily fluids using a simple magnet.

The method was faster, more accurate and less expensive compared to current detection methods and the nanobeads could be produced at high volume in industrial cell factories reducing the cost of analysis. The two-step strategy uses nanobeads to magnetically isolate the cancer biomarkers, such as methylated DNA or exosomes, from blood or tissue samples collected from cancer patients. 

The principle of detection of these biomarkers is based on the specificity of antibodies between the antibody and target molecules. Here, exosomes represent protein-based biomarkers whereas methylated DNA represent DNA-based biomarkers.

This method represents a diagnostic platform that can be adapted to a wider variety of protein and DNA-based biomarkers to enable the diagnosis of various diseases. The demand for point-of-care diagnostics and monitoring was rapidly increasing with the increase in the prevalence of chronic diseases, healthcare costs and unmet healthcare needs.

Huge research efforts have been devoted towards the development of technologies that can detect cancer at early stages, it was noted. However, the main challenge that many health systems face is finding a method that is cheap, rapid and accurate. These nanomaterials could provide a way to overcome some of these challenges.

The most conventional diagnostic methods used expensive biological kits and relied on sophisticated equipment, limiting their use in developing countries and other resource-poor settings. Early diagnosis of cancer is critical for more effective treatment strongly improving the prognosis of patients so it is important to develop versatile diagnostic platform technologies that are specific and sensitive to detect cancer.

Recent research noted that global cancer/tumour profiling market size is projected to reach US$ 13.9 billion by 2025 from US$ 8.3 billion in 2020, at a CAGR of 10.9% during the forecast period.

The increasing incidence of cancer across the globe and the growing use of biomarkers in tumour profiling are the primary growth drivers for this market. In addition, the increase in cancer research and funding initiatives and technological advancements in profiling technologies are also propelling the growth of cancer/tumour profiling market.

Also, the increasing demand for personalised medicine and the growing need for point-of-care diagnostics is expected to offer significant growth opportunities for market players during the forecast period. On the other hand, the high capital investment required for biomarker discovery and the technical issues with sample collection and storage is the key factors restraining market growth to a certain extent.

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Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

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CTC Global Singapore, a premier end-to-end IT solutions provider, is a fully owned subsidiary of ITOCHU Techno-Solutions Corporation (CTC) and ITOCHU Corporation.

Since 1972, CTC has established itself as one of the country’s top IT solutions providers. With 50 years of experience, headed by an experienced management team and staffed by over 200 qualified IT professionals, we support organizations with integrated IT solutions expertise in Autonomous IT, Cyber Security, Digital Transformation, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Well-known for our strengths in system integration and consultation, CTC Global proves to be the preferred IT outsourcing destination for organizations all over Singapore today.

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Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

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SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

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HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

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IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.

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