February 29, 2024

We are creating some awesome events for you. Kindly bear with us.

Indian, US Scientists Develop Brain Tissues With 3D Printed Bioreactor

Scientists at the Indian Institute of Technology in Madras (IIT-Madras) and Massachusetts Institute of Technology (MIT) in the US, have grown human brain tissues called ‘organoids’ using a 3D Printed Bioreactor that they developed.

According to a report, the objective was to observe the brain tissues while they grow and develop, a technology that can potentially accelerate medical and therapeutic discoveries. The invention will help revolutionise treatment developments for diseases such as spinal cord injury, diabetes, rheumatoid arthritis, cerebral palsy, Alzheimer’s, Parkinson’s, and targeted cancer treatment. the organoid-based diagnosis is also useful for screening pharmaceutical compounds.

The current cell culture protocols involve separate chambers for incubation and imaging, requiring that cells be physically transferred to the imaging chamber, which poses the risk of false results and chances for contamination. However, the team has come up with a novel solution, which lets the cells grow uninterruptedly. A 3D-printed micro-incubator and imaging chamber was made into a single palm-sized platform, which was successfully demonstrated for long-term human brain cells culture and real-time imaging.

The scientists designed a microfluidic chip for the imaging and culturing of organoids. This ensures the long-term growth of organoids into a 3D spheroid form. A transparent glass disk with a thickness of 150m was placed on what researchers call a ‘Matrigel’ (extracellular environment matrix of polymers) that provided an optical window for live-organoid imaging. The chip was then put on a heating plate.  The microfluidic chip was made using stereolithography-based 3D printing technology. It was refined using the 3D CAD modelling software. The printed chip was then cured by exposure to UV light and then connected to an incubator environment for the growth of organoids.

“The design from this research is a scalable microfluidic technology in which copies of an organoid can be grown simultaneously in different wells, for studies in basic and applied science,” Professor Anil Prabhakar, Department of Electrical Engineering, IIT-Madras, said in a statement. He added that the bioreactor can be completely automated with different protocols, and used for drug discovery, thus drastically reducing labour costs, errors, and time to market. Different environmental sensors can be combined with this micro-incubator and the device fits with most of the microscopes for live-cell imaging.

The technology has been patented in India. The research team is exploring the feasibility of international collaborations. The project was executed with support from the Centre for Computational Brain Research (CCBR) at IIT-Madras for funding and Sur’s Lab at MIT. Considering the importance of the micro-incubator in the field of healthcare and the pharmaceutical industry, the team is working through ISMO bio-photonics to develop a user-friendly minimum viable product and raising seed grants for its further development. This will enable biologists or laboratory technicians to operate, control, and monitor the growth of organoids with a user-friendly system powered by artificial intelligence (AI)-assisted automated cell culture protocol.

The findings of this research were recently published in the peer-reviewed international journal Biomicrofluidics. Cell culture is one of the fundamental steps in validation of the human organ model, whether it may be a pre-clinical study for COVID-19, cancer medicine discovery, or any other medicine for humans.

PARTNER

Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

PARTNER

CTC Global Singapore, a premier end-to-end IT solutions provider, is a fully owned subsidiary of ITOCHU Techno-Solutions Corporation (CTC) and ITOCHU Corporation.

Since 1972, CTC has established itself as one of the country’s top IT solutions providers. With 50 years of experience, headed by an experienced management team and staffed by over 200 qualified IT professionals, we support organizations with integrated IT solutions expertise in Autonomous IT, Cyber Security, Digital Transformation, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Well-known for our strengths in system integration and consultation, CTC Global proves to be the preferred IT outsourcing destination for organizations all over Singapore today.

PARTNER

Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

SUPPORTING ORGANISATION

SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

PARTNER

HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

PARTNER

IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.

Send this to a friend