Search
Close this search box.

We are creating some awesome events for you. Kindly bear with us.

Singapore Develops Real-time Monitoring with Ingestible X-ray Dosimeter

Image credit : news.nus.edu.sg

One of the most prevalent malignancies worldwide is gastric cancer and by increasing the accuracy of radiotherapy, which is frequently combined with treatment choices like surgery, chemotherapy, or immunotherapy, researchers from the National University of Singapore (NUS) have developed a novel invention that could aid in the improvement of the treatment of this malignancy.

Precision in targeting tumour tissue while minimising damage to healthy tissue is essential in the practice of contemporary radiotherapy. However, due to patient diversity, treatment ambiguity, and variations in delivery forms, low efficacy and varied outcomes continue to be a problem.

Real-time dosage monitoring, particularly in the gastrointestinal system, could improve the accuracy of radiotherapy and increase its efficacy, but it is challenging to implement. Additionally, the current techniques for tracking biochemical parameters like pH and temperature are insufficient for a thorough assessment of radiation.

The research team has created an ingestible X-ray dosimeter that measures radiation exposure in real-time to overcome this difficulty. To determine the amount of radiation absorbed in the target area, clinical dosimeters such as metal-oxide-semiconductor field-effect transistors, thermoluminescence sensors, and optically stimulated films are frequently applied directly to or close to the patient’s skin.

While such dosimetry with electronic portal imaging devices has been considered for treatment verification, these devices can be costly and absorb radiation, reducing the patient’s intended dose. Thus, there is a need for a low-cost swallowable sensor that can measure biochemical markers and X-ray dosage absorption simultaneously during gastrointestinal radiotherapy because ingestible sensors are only capable of measuring pH and pressure.

To overcome these limitations, the research team devised a novel ingestible X-ray dosimeter capsule capable of measuring the radiation dose and physiological changes in pH and temperature in real-time during gastrointestinal radiotherapy.

A flexible optical fibre encapsulated with nano-scintillators that light up in the presence of radiation, a pH-responsive film, a fluidic module with multiple inlets for dynamic gastric fluid sampling, two sensors for dose and pH measurements, a microcontroller circuit board that processes photoelectric signals to be transmitted to a mobile application, and a button-sized silver oxide battery power the capsule.

When the capsule is ingested and reaches the gastrointestinal tract, the nano-scintillators will glow brighter in the presence of increased X-ray radiation; and to determine the amount of radiation given to the targeted area, a sensor within the capsule analyses the brightness of the nano-scintillators.

Additionally, the fluidic module permits the collection of gastric fluid for pH detection using a colour-changing film. Within the capsule, a second sensor detects this change in hue. In addition, the two sensors can detect temperature, which may indicate adverse reactions to radiotherapy, such as allergies.

The photoelectric signals from the two sensors are processed by a microcontroller circuit board, which transmits data to a mobile phone application via Bluetooth technology and an antenna. The mobile app analyses the raw data using a neural network-based regression model to display information such as the radiotherapy dose, temperature, and pH of the tissues undergoing radiotherapy.

Currently designed to monitor radiotherapy doses for gastric cancer, the capsule could also be used to monitor treatment for other malignancies if its dimensions were modified.

The research team is working towards the clinical deployment of their innovation. Classifying the capsule’s position and posture after ingestion, emerging a robust positioning system to anchor the capsule at the intended target site, and further calibrating the accuracy of ingestible dosimeters for safe and effective clinical use are among the next steps in the research process.

PARTNER

Qlik’s vision is a data-literate world, where everyone can use data and analytics to improve decision-making and solve their most challenging problems. A private company, Qlik offers real-time data integration and analytics solutions, powered by Qlik Cloud, to close the gaps between data, insights and action. By transforming data into Active Intelligence, businesses can drive better decisions, improve revenue and profitability, and optimize customer relationships. Qlik serves more than 38,000 active customers in over 100 countries.

PARTNER

As a Titanium Black Partner of Dell Technologies, CTC Global Singapore boasts unparalleled access to resources.

Established in 1972, we bring 52 years of experience to the table, solidifying our position as a leading IT solutions provider in Singapore. With over 300 qualified IT professionals, we are dedicated to delivering integrated solutions that empower your organization in key areas such as Automation & AI, Cyber Security, App Modernization & Data Analytics, Enterprise Cloud Infrastructure, Workplace Modernization and Professional Services.

Renowned for our consulting expertise and delivering expert IT solutions, CTC Global Singapore has become the preferred IT outsourcing partner for businesses across Singapore.

PARTNER

Planview has one mission: to build the future of connected work. Our solutions enable organizations to connect the business from ideas to impact, empowering companies to accelerate the achievement of what matters most. Planview’s full spectrum of Portfolio Management and Work Management solutions creates an organizational focus on the strategic outcomes that matter and empowers teams to deliver their best work, no matter how they work. The comprehensive Planview platform and enterprise success model enables customers to deliver innovative, competitive products, services, and customer experiences. Headquartered in Austin, Texas, with locations around the world, Planview has more than 1,300 employees supporting 4,500 customers and 2.6 million users worldwide. For more information, visit www.planview.com.

SUPPORTING ORGANISATION

SIRIM is a premier industrial research and technology organisation in Malaysia, wholly-owned by the Minister​ of Finance Incorporated. With over forty years of experience and expertise, SIRIM is mandated as the machinery for research and technology development, and the national champion of quality. SIRIM has always played a major role in the development of the country’s private sector. By tapping into our expertise and knowledge base, we focus on developing new technologies and improvements in the manufacturing, technology and services sectors. We nurture Small Medium Enterprises (SME) growth with solutions for technology penetration and upgrading, making it an ideal technology partner for SMEs.

PARTNER

HashiCorp provides infrastructure automation software for multi-cloud environments, enabling enterprises to unlock a common cloud operating model to provision, secure, connect, and run any application on any infrastructure. HashiCorp tools allow organizations to deliver applications faster by helping enterprises transition from manual processes and ITIL practices to self-service automation and DevOps practices. 

PARTNER

IBM is a leading global hybrid cloud and AI, and business services provider. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Nearly 3,000 government and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and business services deliver open and flexible options to our clients. All of this is backed by IBM’s legendary commitment to trust, transparency, responsibility, inclusivity and service.